What is the Connection Between Phentermine and Fen-Phen? :

Phentermine and Fen-Phen connectionWhat is the Connection Between Phentermine and Fen-Phen?

In the early 90s, Fenphedrine, also known as Fen-Phen, was approved as a prescription drug in order to give dieters a new way to help to get thin when nothing else seemed to have been working.

What Are Phentermine and Fen-Phen?

This drug was a combination of two other prescription diet medications, fenfluramine and phentermine. That said, by September 1997, that drug was taken right back off the market, again, in the United States. The reason was that there were large numbers of reports of adverse reactions to the drug that were flooding in throughout the time that it was legal to use.

Dangerous Reactions to Fen-Phen

Among some of those reactions were some very dangerous ones, such as abnormalities to the aortic, mitral, and tricuspid heart valves, and even fatalities as a result of pulmonary hypertension – a deadly condition of the lungs. From July to September 1997, alone, there were at least 90 cases of a rare heart valve disease reported in people who were taking this medication. There was also a disproportionate number of patients who were taking this medication who had abnormal readings on their echocardiogram tests, regardless of the fact that they did not have any obvious symptoms.

What was even more scary about the legal use of this drug was that Fen-Phen actually obtained its FDA approval based on the results of one study that involved the participation of only 121 obesity patients. Not only is that a tiny sample that is hardly representative of the general population, but the results weren’t all that impressive. Among them, the average weight loss was 30 pounds over a period of four years. That means that the drug received approval based on effects that brought about an average of just over half a pound of weight loss per month. Still, it was virtually labeled a “miracle cure” and the prescriptions started flowing out like water.

Banning Fenfluramine in the United States

Fenfluramine, itself, was also taken off the market after being sold as a prescription drug for twenty-four years. This was done at the request of the FDA. The reason was that there was a growing amount of evidence that this medication – as well as another compound that was almost identical, called dexfenfluramine – were greatly cardiotoxic.

What About Phentermine?

Phentermine, on the other hand, continues to be sold as a prescription drug for weight loss. This diet drug is sold under its generic form as well as a number of brands, such as Adipex-P, the most popular among them. It is meant for the treatment of obesity for certain specific patients. It is a drug that is closely related to amphetamines and is known for a range of potential unwanted side effects from mild to severe. That said, many obesity patients have had a great deal of luck in accelerating their weight loss to bring them closer to a healthier body weight.

Adipex Results for Obesity Patients

As Phentermine remains a legal drug, there continue to be positive reports on Adipex results based on safe use.  Obesity patients prescribed this medication don’t automatically lose weight. However, when they are prescribed it alongside lifestyle change recommendations – as doctors are meant to do – such as a calorie restricted diet and regular physical activity.

When combined with these types of lifestyle changes, obesity patients frequently find that they find it easier to lose weight than it would have been if they tried to make those changes unassisted.  The pills work as a tool to decrease the challenge level associated with creating these new habits.  They eliminate – or at least reduce – some of the barriers that get in dieters’ way and that can stop them from reaching their goals.

That said, while Phentermine is still FDA-approved as an obesity treatment tool, it’s important to remember that it remains a serious drug.  There are side effects associated with its use, ranging from mild to severe.  This drug is also habit forming.  Its use – particularly if not taken precisely according to the doctor’s directions – can lead to addiction and uncomfortable withdrawal symptoms.